FEATURED PUBLICATIONS

Frailty and CVD in the elderly share pathophysiological mechanisms and associated conditions, such as malnutrition, sarcopenia, anaemia, polypharmacy and both increased bleeding/thrombotic risk. In geriatric populations, acute coronary syndromes are associated with an increased frailty degree. Frail elderly patients are increasingly...

The diagnosis of microvascular disease can be challenging for clinicians. It is an important cause of chest pain, especially In women. Making the correct diagnosis is critical in order to instigate the appropriate therapy and avoid unnecessary downstream investigations. The aim...

Despite the increasing use, better logistics and improved methodology of interventional approaches for coronary reperfusion, the mortality and morbidity from acute myocardial infarction are still substantial. This is very clear when examining the real world data. This issue is complex: patients...

It Is known from several studies that coronary microvascular dysfunction (CMD) is an independent predictor of future adverse cardiovascular events in healthy volunteers, patients with non-obstructive coronary artery disease (CAD), and patients with ST-elevation myocardial infarction. However, the relationship between aortic...

The management of chronic stable angina encompasses lifestyle modification, control of risk factors for coronary artery disease, and both invasive and noninvasive treatment. Pharmacological therapy has two main goals: firstly to alleviate symptoms, increase angina-free walking time, and improve quality of...

In this clinical discussion, WE Boden and GBJ Mancini, describe a clinical scenario of a physically active man with stable Coronary Artery Disease (CAD). The patient was largely asymptomatic with only occasional symptoms of presumed angina at a high workload. He...

In the ISCHEMIA trial, an invasive strategy with angiographic assessment and revascularization did not reduce clinical events among patients with stable ischemic heart disease and moderate or severe ischemia. A secondary objective of the trial was to assess angina-related health status...

This article provides an interesting follow-up to the 1st webinar of the Angina Updates initiative. In this review by RE Konst et al. (Including Prof Kaski, one of our editors), explain very elegantly how different factors are involved in coronary microvascular...

Disorders of coronary vasomotion include epicardial and/or microvascular coronary spasm, impaired coronary artery vasorelaxation and endothelial dysfunction-related reduced myocardial blood flow. Various vasoactive substances may be implicated. Endothelin-1 (ET-1), a 21 amino acid peptide, is a potent vasoconstrictor which has long...

Diffuse and focal epicardial coronary disease and coronary microvascular abnormalities may exist side-by-side. Coronary microvascular dysfunction (CMD) may explain why angina persists in a substantial portion of patients after successful revascularisation. This review by U. Sechtem et al. (Robert Bosch Krankenhaus,...