FEATURED PUBLICATIONS

Target therapy explores treatment with specific therapeutic drugs against pathogenic molecules or cells to ensure normal, healthy tissue is not affected. This allows the possibility of personalised, precise treatment. The most common targeted therapies include treatments such as protein or nucleic...

Leukocyte-shed extracellular vesicles have been found to play effector roles in the pathophysiology of many different diseases. There are often high levels of leukocyte-shed extracellular vesicles found in inflamed tissues; this indicates immunity cell activation. Within this study, the link between...

The question was posed of whether myocardial perfusion imaging can predict the outcomes of patients with angina and ischemia with no obstructive coronary artery disease (INOCA). It was found that in INOCA patients, perfusion abnormalities were seen, which may be due...

The ISCHEMIA trial compared two strategies for patients with chronic coronary disease and moderate to severe ischemia: conservative management versus invasive management. However, no major differences were discovered after a follow-up of around 3.2 years. After 5.7 years, there was seen...

Endothelial dysfunction has been noticed to be linked to cardiovascular events such as myocardial infarction and unstable angina, especially for patients with INOCA (ischaemia with no obstructive coronary artery disease). Endothelial dysfunction occurs when there is a limited availability of nitric...

Chronic heart failure is a very serious, disabling condition which brings around significant impacts. One of the main issues to note is the effect of chronic heart failure on the patient’s social life. This condition can lead to a decreased social...

A coronary artery bypass graft is a surgical procedure used in patients with coronary artery disease. Its goal is to relieve symptoms of angina, slow the progression of ischemic heart disease, and, in turn, increase quality of life and life expectancy....

The prevalence of diabetes is increasing across the globe, with an estimated 8.5% of adults globally suffering from this condition. However, there is little data discussing the relationship between diabetes mellitus and chronic coronary syndromes. There are significant differences in the...

A recent trial by the International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (ISCHEMIA) addressed the idea of treating ischemia with invasive approaches to improve outcomes. They investigated whether this would prove more beneficial than non-invasive approaches, such...

Hypertrophic cardiomyopathy is the most common inherited heart diseases. Yet, there is currently no specific course of management or treatment for patients suffering with hypertrophic cardiomyopathy which modifies disease expression. This review synthesised current therapies, finding that invasive septal reductions increase...