Published date : 15 November 2022

Endothelial dysfunction pose high risk of mayor CV events

Heart failure
Reviewed by
Z. Beketova
Published in
Int J Cardiol 2022
Authors
Grigorian-Shamagian L, Oteo JF, Gutiérrez-Barrios A, et al.
Link to original article link
https://pubmed.ncbi.nlm.nih.gov/36328111/
Commentary

Endothelial dysfunction has been noticed to be linked to cardiovascular events such as myocardial infarction and unstable angina, especially for patients with INOCA (ischaemia with no obstructive coronary artery disease). Endothelial dysfunction occurs when there is a limited availability of nitric oxide in the cells. This study, with 438 patients and a follow-up duration of 2 years, concluded that endothelial dysfunction predicts worse symptoms and higher rates of adverse cardiovascular events. However, endothelial dysfunction can be reversed if diagnosed early – this underscores the importance of considering this risk factor with early diagnosis.

This review by Grigorian-Shamagian L et al. aimed to understand the link between endothelial dysfunction and ischaemia with no obstructive coronary artery disease.

Key learnings:

Further research is necessary into fully understanding the links between endothelial dysfunction and ischaemia, angina and myocardial infarction. These studies will allow for better-informed management of these conditions.

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