FEATURED PUBLICATIONS

Coronary microvascular dysfunction (CMD) is a common condition which often correlates with adverse cardiovascular events in those with diabetes mellitus. A recently developed method of assessing coronary microvascular dysfunction, coronary angiography-derived index of microcirculatory resistance (caIMR), is wire- and hyperaemic agent...

There is a lack of data surrounding the use of percutaneous coronary intervention (PCI) for stable ischemic heart disease, especially in older patients. This study evaluated the risks of this approach, with 74,516 patients who had undergone PCI for stable ischemic...

Allogeneic hematopoietic cell transplantation (allo-HCT) is a therapeutic method that holds the potential to cure hematological disorders. However, there can be severe complications, including cardiotoxicity. This can occur due to cytotoxic agents or inflammatory mediators which cause tissue damage or infections....

Recent studies have indicated that the blood microbiota may play a role in cardiovascular disease (CVD). Bacteria may influence circulation via atherosclerosis and thrombosis, and chronic infections have been associated with CVD risk. As such, recent studies have hypothesised that the...

It is estimated that 4% of patients with heart failure suffer from an ischaemic stroke. However, the magnitude of this problem has not been properly examined due to the variability of the condition within the population and the commonality of various...

A crucial factor in the development of cardiovascular diseases is physical inactivity. This was confirmed by Buckley BJR et al’s study, where prescribing exercise as a form of cardiac rehabilitation showed associations with reduced risk of all-cause death and rehospitalisation at...

Guideline-directed medical therapy (GDMT) is recommended as a clinical guideline for patients suffering from heart failure with reduced ejection fraction, also known as HFrEF. This therapy includes treatments such as beta-blockers, mineralocorticoid receptor antagonists (MRAs), ARNI and SGLT2 inhibitors (to be...

Guideline-directed medical therapy (GDMT), which includes treatment using SGLT2 inhibitors and angiotensin receptor-neprilysin inhibitor (ARNI), has been proven to significantly reduce mortality and morbidity in patients with heart failure with reduced ejection fraction (HFrEF). The latest guideline recommends these drugs for...

Increased heart rate (HR) is associated with cardiovascular events (CVE) in the general population, in those with cardiovascular risk factors, and in patients with coronary artery disease (CAD). Further, it is well-known that in patients with heart failure (HF), low HR...

Up to half of patients undergoing elective coronary angiography for chest pain do not possess obstructive coronary artery disease. Due to a lack of investigation into the potentially ischaemic basis of their condition, these patients’ symptoms are often dismissed and access...